Tetrahedron

Synthesis of 10-substituted “open-chain” analogues of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolic acid (DDATHF, Lometrexol)

EC Taylor, TH Schrader, LD Walensky

文献索引：Taylor, Edward C.; Schrader, Thomas H.; Walensky, Loren D. Tetrahedron, 1992 , vol. 48, # 1 p. 19 - 32

全文：HTML全文

被引用次数: 23

摘要

Several novel and very potent folate antimetabolites, structurally based upon our previously described “open-chain” version of DDATHF but carrying 1-carbon substituents in the 10- position, have been synthesized. A key synthetic sequence involving a palladium-catalyzed C C coupling reaction, oxymercuration, and Wittig olefination constitutes a new route to α- branched 4-styrene carboxylic acids. Classical construction of the pyrimidine ring from the ...