Abstract: The rates of reaction of the TiC14 complexes of two diastereomeric 1- (methoxymethy1)-1-propyldecahydro-naphthalen-2-ones (la and le) with trimethylsilyl cyanide have been measured for the purpose of determining the preferred complexation geometry for the activation of carbonyls toward nucleophilic addition. Compound la incorporates an axial methoxymethyl group which is designed to steer complexation of ...
