Tetrahedron Letters

Diastereoselective [3+ 2] cycloadditions of a camphor-derived chiral N-acryloylhydrazide with nitrile oxides: the preparation of optically pure Δ 2-isoxazolines

KS Yang, JC Lain, CH Lin, K Chen

文献索引：Yang, Kung-Shuo; Lain, Jung-Chaing; Lin, Chun-Hui; Chen, Kwunmin Tetrahedron Letters, 2000 , vol. 41, # 9 p. 1453 - 1456

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被引用次数: 24

摘要

Dipolar cycloadditions constitute one of the most powerful classes of reactions for the construction of useful and versatile synthetic intermediates in organic synthesis. 1 In particular, cycloadditions involving nitrile oxides as dipoles have been extensively examined and applied towards the total synthesis of many biologically active natural products. 2 a–g The development of an efficient route to an optically active isoxazoline ring system is important because its reaction with ...