Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2, 4-diaminoquinazolines

…, LF Kuyper, DP Baccanari, SS Joyner…

文献索引：Chan; Hong; Kuyper; Baccanari; Joyner; Tansik; Boytos; Rudolph Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3608 - 3616

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被引用次数: 51

摘要

The increasing occurrence of systemic fungal infections, particularly among AIDS patients, has stimulated the search for better antifungal agents. l In a program aimed at identifylng novel antifungal agents, we focused on developing compounds that would selectively inhibit the enzyme dihydrofolate reductase (DHFR) from fungal species. Inhibition of DHFR is a well-established mechanism of drug action. 2 DHFR catalyzes the reduction of ...