View all references). Certain plant-derived compounds were found to be highly effective against insecticide resistant insect pests. For example, Piper nigrum fruits-derived guineensine exhibits remarkable lethal activity against a pyrenthrin-resistant strain of Musca domestica. The insecticidal constituents of piper fruits are N-isobutyl amide alkaloids such as dihydropipercide, guineensine, pellitorine and pipercide. These isobutyl amides have knock down activity ...