18F-Glyco-RGD peptides for PET imaging of integrin expression: efficient radiosynthesis by click chemistry and modulation of biodistribution by glycosylation

S Maschauer, R Haubner, T Kuwert…

文献索引：Maschauer, Simone; Haubner, Roland; Kuwert, Torsten; Prante, Olaf Molecular Pharmaceutics, 2014 , vol. 11, # 2 p. 505 - 515

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被引用次数: 33

摘要

Glycosylation frequently improves the biokinetics and clearance properties of macromolecules in vivo and could therefore be used for the design of radiopharmaceuticals for positron emission tomography (PET). Recently, we have developed a click chemistry method for 18F-fluoroglycosylation of alkyne-bearing RGD-peptides targeting the integrin receptor. To investigate whether this strategy could yield an 18F-labeled RGD ...