Toward protein-cleaving catalytic drugs: artificial protease selective for myoglobin

JW Jeon, SJ Son, CE Yoo, IS Hong, J Suh

文献索引：Jeon, Joong Won; Son, Sang Jun; Yoo, Chang Eun; Hong, In Seok; Suh, Junghun Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2901 - 2910

全文：HTML全文

被引用次数: 55

摘要

A protein-cleaving catalyst highly selective for a disease-related protein can be used as a catalytic drug. As the first protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin (Mb) was designed by attaching the Cu (II) or Co (III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units. Various linkers were inserted between the catalytic Co (III) center and the ...