Tetrahedron Letters

A high yield synthesis of (±)-5, 8-dimethoxy-2-α-hydroxyethyl-3, 4-dihydronaphthalene, a key intermediate in anthracyclinone synthesis

MP Reddy, GS Krishna

文献索引：Reddy, M. Parameswara; Rao, G. S. Krishna Tetrahedron Letters, 1981 , vol. 22, # 36 p. 3549 - 3550

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被引用次数: 14

摘要

Summary: The dimethoxytetralol (2) gives on Vilsmeier reaction the dihydronaphthaldehyde (3)(yield, 92%), wbch on Grignard reaction with MeMgI affords the title compund (5)(yield, rYlOO%), the reactions constituting a high yield synthesis of: this imwrtanf anthracyclinone