Synthesis and antileishmaniasis activity of 2-[2′-chlorostyryl]-4-[δ-diethyl-amino-α-methylbutylamino]-7-chloroquinazoline diphosphate

LN Yakhontov, GP Zhikhareva, LI Mastafanova…

文献索引：Yakhontov, L. N.; Zhikhareva, G. P.; Mastafanova, L. I.; Evstratova, M. I.; Pershin, G. N.; et al. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 34 - 45 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 38 - 49

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被引用次数: 2

摘要

Four drugs are currently used in the USSR for the treatment of dermal leishmaniasis, these having specific effects on the causative agents of the disease [3]. These are acriquin, solusurmin, monomycin, and aminoquinol. Systemic treatment of visceral and dermal leishmaniases abroad is usually carried out with pentavalent antimony compounds, namely an analog of solusurmin (pentostam) and glucanthlm [i0, 14, 15]. However, acriquin is ...