A series of synthetic lipids containing a two-or three-carbon backbone substituted with a thio, oxy, or amidoalkyl functionality and either a phosphocholine or quaternary ammonium moiety was evaluated as potential anti-HIV-1 agents. Several analogues were identified as possessing activity with the most promising compound being rac-3-octadecanamido-2- etholrypropylphosphocholine (8). Compound 8 exhibited an ICso for the inhibiton of ...
