Synthetic Communications

Novel Method of Synthesizing Various Five Membered Heterocycles from an Aryl Tribromomethyl Group

R Tynebor, E Millings

文献索引：Tynebor, Robert; Millings, Elizabeth Synthetic Communications, 2013 , vol. 43, # 14 p. 1902 - 1908

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摘要

Synthesis of five membered heterocycles from an aryl tribromomethyl functional group is discussed. Exposing a tribromomethyl group to subsequent nucleophilic attacks by a 1,2-di-nucleophilic species promotes the cyclization of five membered heterocycles. Such heterocycles as oxadiazoles, thiadiazole, benzimidazole, benzothioazole, and benzoxazole were synthesized in moderate to good yields. ... Supplemental materials are available for this article. Go to ...