Synthesis of Optically Active Thromboxane A 2 and Leukotriene D 4 Receptor Antagonists

S Kawazoe, Y Okamoto, M Yokota, H Kubota…

文献索引：Kawazoe, Souichirou; Okamoto, Yoshinori; Yokota, Masaki; Kubota, Hirokazu; Naito, Ryo; Takeuchi, Makoto; Ieda, Shigeru; Okada, Minoru; Oriyama, Takeshi Bulletin of the Chemical Society of Japan, 2014 , vol. 87, # 1 p. 127 - 140

全文：HTML全文

被引用次数: 3

摘要

Both (+)-and (−)-4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)-vinyl] phenyl} ethyl) thio] methyl} benzoic acid (1), Thromboxane A 2 and Leukotriene D 4 receptor dual antagonist were synthesized. Racemic methyl 4-({[2-amino-1-(3-hydroxymethylphenyl) ethyl] thio} methyl) benzoate (2), and methyl 4-[({2-amino-1-[3-(1, 3-dioxolan-2-yl) phenyl] ethyl} thio) methyl] benzoate (3) were derived from 2-(3-bromophenyl)-1, 3-dioxolane (4). ...