Tetrahedron

Improved synthesis of (R)-glycine-d-15 N

JR Walker, RW Curley

文献索引：Walker, Joel R; Curley Jr., Robert W Tetrahedron, 2001 , vol. 57, # 31 p. 6695 - 6701

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被引用次数: 13

摘要

Previously, we have synthesized the title glycine to permit assignment of the prochiral α- protons of glycine residues in the NMR study of the protein FKBP. A key, and low yielding step in this synthesis occurs in the ruthenium tetraoxide mediated degradation of Nt-Boc-p- methoxybenzyl amine to Nt-Boc-glycine. Efforts to improve this key step by exploring different substrates and N-protecting groups were successful to render this synthesis ...