Tetrahedron letters

Simple syntheses of the polyamine alkaloid tenuilobine and analogues using selectively N-tritylated polyamines and dicarboxylic acids as bridging elements

…, I Govaris, K Voyagi, P Mamos, D Papaioannou

文献索引：Vassis, Stratos; Govaris, Ioannis; Voyagi, Katerina; Mamos, Petros; Papaioannou, Dionissios Tetrahedron Letters, 2002 , vol. 43, # 14 p. 2597 - 2600

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被引用次数: 16

摘要

Selectively N-tritylated spermidine and spermine derivatives and the monophenacyl ester of 1, 16-hexadecanedioic acid (Hda) were used to obtain the polyamine alkaloid tenuilobine and its fully reduced analogue. Other symmetric or side-chain-shortened tenuilobine analogues were readily obtained by using Hda or its dichloride or succinic anhydride to bridge the polyamine moieties.