Highly active palladium catalysts for Suzuki coupling reactions

…, RA Singer, BH Yang, SL Buchwald

文献索引：Wolfe, John P.; Singer, Robert A.; Yang, Bryant H.; Buchwald, Stephen L. Journal of the American Chemical Society, 1999 , vol. 121, # 41 p. 9550 - 9561

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被引用次数: 1073

摘要

Mixtures of palladium acetate and o-(di-tert-butylphosphino) biphenyl (4) catalyze the room- temperature Suzuki coupling of aryl bromides and aryl chlorides with 0.5-1.0 mol% Pd. Use of o-(dicyclohexylphosphino) biphenyl (2) allows Suzuki couplings to be carried out at low catalyst loadings (0.000001-0.02 mol% Pd). The process tolerates a broad range of functional groups and substrate combinations including the use of sterically hindered ...