A catalytic antibody elicited by a hapten of tetrahedral carbon-type

T Kitazume, T Tsukamoto, K Yoshimura

文献索引：Kitazume, Tomoya; Tsukamoto, Takashi; Yoshimura, Koutaro Journal of the Chemical Society, Chemical Communications, 1994 , # 11 p. 1355 - 1356

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被引用次数: 8

摘要

A monoclonal antibody, elicited by a α, α, α′, α′-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for the oxygen atom in an ether.