2-Mercaptoacetamidine and derivatives as antiradiation agents

RD Westland, MM Merz, SM Alexander…

文献索引：Westland; Merz; Alexander; Newton; Bauer; Conway; Barton; Khullar; Devdhar; Grenan Journal of medicinal chemistry, 1972 , vol. 15, # 12 p. 1313 - 1321

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被引用次数: 18

摘要

N-Substituted-2-mercaptoacetamidines and functional derivatives, including the corresponding disulfides, Bunte salts, and phosphorothioates, have been synthesized and found as a class to be highly effective antiradiation agents. Variations in the N substituent include alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, hydroxyalkyl, cycloalkyloxyalkyl, aryloxyalkyl, thioethers, and heteroaralkyl groups. A synthesis other than the conventional ...