Carry over of impurities: a detailed exemplification for glycopyrrolate (NVA237)

T Allmendinger, D Bixel, A Clarke…

文献索引：Organic Process Research and Development, , vol. 16, # 11 p. 1754 - 1769

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摘要

... Organic Process Research & Development. ... The original synthesis of glycopyrrolate (NVA237) was revised and shortened into an essentially one-pot process. ... usual activations of 1—eg, as acid chloride—are not possible; following the original procedure patented in 1960,(5, 6 ...