Novel 1-Phenylcycloalkanecarboxylic Acid Derivatives Are Potent and Selective. sigma. 1 Ligands

SN Calderon, S Izenwasser, B Heller…

文献索引：Calderon, Silvia N.; Izenwasser, Sari; Heller, Brett; Gutkind, J. Silvio; Mattson, Mariena V.; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2285 - 2291

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被引用次数: 21

摘要

Carbetapentane (1, 2424 diethylamino) ethoxy] ethyl l-phenyl-l-cyclopentanecarboxylate) binds with high affinity to 0 sites and is a potent antitussive, anticonvulsant, and spasmolytic agent. However, carbetapentane interacts at muscarinic binding sites as well, and it is not clear whether either of these receptor systems is involved in the mechanism ($ of action (s) of this drug. In an attempt to determine whether these psychoactivities can be attributed to ...