Structure-activity studies of 4, 6-disubstituted 2-(morpholinocarbonyl) furo [3, 2-b] indole derivatives with analgesic and antiinflammatory activities

Y Kawashima, F Amanuma, M Sato…

文献索引：Kawashima, Yutaka; Amanuma, Fusao; Sato, Masakazu; Okuyama, Shigeru; Nakashima, Yoshimoto; et al. Journal of Medicinal Chemistry, 1986 ,  vol. 29,  # 11  p. 2284 - 2290

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被引用次数: 17

摘要

4, 6-Disubstituted 2-(morpholinocarbonyl) furo [3, 2-b] indole derivatives showed analgesic and antiiiatory activities when assayed by the acetic acid writhing test in mice and the carrageenin edema test in rats. To understand how the substituents affect the biological activities, the quantitative structureactivity relationships (QSAR) of 38 compounds were analyzed using the adaptive least-squares method (ALS method). The resulting QSAR ...