A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2, 2′-dithiobisbenzamides

…, PJ Tummino, J Scholten, P Harvey, T Holler…

文献索引：Domagala, John M.; Bader, John P.; Gogliotti, Rocco D.; Sanchez, Joseph P.; Stier, Michael A.; Song, Yuntao; Vara Prasad; Tummino, Peter J.; Scholten, Jeffrey; Harvey, Patricia; Holler, Tod; Gracheck, Steve; Hupe, Donald; Rice, William G.; Schultz, Robert Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 3 p. 569 - 579

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被引用次数: 48

摘要

As part of the National Cancer Institute's Drug Screening Program, a new class of antiretrovirals active against the human immunodeficiency virus HIV-1 has been identified, and the HIV-1 nucleocapsid protein NCp7 was proposed as the target of antiviral action. The 2, 2′-dithiobis-[4′-(sulfamoyl) benzanilide](3x) and the 2, 2′-dithiobis (5-acetylamino) benzamide (10) represented the prototypic lead structures. A wide variety of 2, 2′- ...