Preparation and pharmacological evaluation of enantiomers of certain nonoxygenated aporphines:(+)-and (-)-aporphine and (+)-and (-)-10-methylaporphine

…, R Raghupathi, ST Moe, AK Johnson…

文献索引：Cannon, Joseph G.; Raghupathi, Revathi; Moe, Scott T.; Johnson, Alan K.; Long, John Paul Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1316 - 1318

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被引用次数: 15

摘要

The subject compounds were prepared as a part of a continuing structure-activity study of the contrasting actions (agonism-antagonism) of (+)-and (-)-11-hydroxy-10-methylaporphine at serotonin (B-HT~ A) receptors. None of the targeted nonoxygenated aporphine derivatives demonstrated significant activity in assays for any effects at serotonin~-HT~ A receptors. It is concluded that, in the aporphine series, serotonergic agonist or antagonism ...