Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7 H-[1, 4] Oxazino [3, 2-g] quinolin-7-ones

…, YO Long, TK Jones, JP Edwards, L Zhi…

文献索引：Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K. Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639

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被引用次数: 38

摘要

Recent interest in orally available androgens has fueled the search for new androgens for use in hormone replacement therapy and as anabolic agents. In pursuit of this, we have discovered a series of novel androgen receptor modulators derived from 7 H-[1, 4] oxazino [3, 2-g] quinolin-7-ones. These compounds were synthesized and evaluated in competitive binding assays and an androgen receptor transcriptional activation assay. A number of ...