A Practical Regioselective Synthesis of Alkylthio-or Arylthioindoles without the Use of Smelly Compounds Such as Thiols

T Hamashima, Y Mori, K Sawada, Y Kasahara…

文献索引：Hamashima, Toshihiko; Mori, Yoshiaki; Sawada, Kazunori; Kasahara, Yuko; Murayama, Daisuke; Kamei, Yuto; Okuno, Hiroaki; Yokoyama, Yuusaku; Suzuki, Hideharu Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 3 p. 292 - 303

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被引用次数: 3

摘要

A convenient method for the synthesis of 3-methylthioindoles has been established which does not use smelly compounds such as thiol derivatives. The method, which introduces an alkyl-or arylthio-group into the C 3-position of the indole skeleton, was extended to the direct introduction of a methylthio or bromo group at the C 2-position using 3-methylthioindoles. No dimerization occurred, and the reaction mechanism was confirmed. The products have the ...