Synlett

Simple methodology for the synthesis of meso-unsubstituted β-substituted alkyl porphyrins

S Juillard, G Simonneaux

文献索引：Juillard, Sandrine; Simonneaux, Gerard Synlett, 2006 , # 17 p. 2818 - 2820

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被引用次数: 2

摘要

In our strategy, 1,9-diformyldipyrromethanes 6c and 7c [7] were the key intermediates (Figure [2] ). We first turned to the new dipyrromethane diester 6a, which was prepared from condensation of ethyl 5-acetoxymethyl-4-ethyl-3-methylpyrrole-2-carboxylate with ethyl pyrrole-2-carboxylate in the presence of p-toluenesulfonic acid in dichloromethane solution. The mixture was heated under nitrogen at 40 °C for 48 hours giving 6a in 53% yield. The prerequisite ...