A series of 4 (6)-and 5-phenyl-substituted 2-amino-and 2-[(alkoxycarbonyl) amino]-1, 4, 5, 6- tetrahydropyrimidines 2 were prepared and evaluated for central nervous system (CNS) effects in animal models. Several 5-phenyl-substituted compounds possessed potent antidepressant activity and all compounds in this series were devoid of significant activity in any of the other CNS (anticonvulsant, muscle relaxant, and depressant) assays. The most ...
