Organic letters

Direct Pd-catalyzed arylation of 1, 2, 3-triazoles

S Chuprakov, N Chernyak, AS Dudnik…

文献索引：Chuprakov, Stepan; Chernyak, Natalia; Dudnik, Alexander S.; Gevorgyan, Vladimir Organic Letters, 2007 , vol. 9, # 12 p. 2333 - 2336

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被引用次数: 170

摘要

Motivated by the importance of developing new general methods toward multisubstituted 1,2,3-triazoles, we examined the feasibility of a direct Pd-catalyzed arylation reaction with aryl bromides: a method proved efficient in the highly regioselective C-3 arylation of indolizines. 14 It was found that C-5 arylation of 1,4-disubstituted 1,2,3-triazoles 1a−h in the presence of Pd catalyst and tetrabutylammonium acetate in NMP proceeded smoothly to provide C-5 ...