Tetrahedron: Asymmetry

Lipase-catalyzed resolution of 2-azabicyclo [2.2. 1] hept-5-en-3-ones

H Nakano, K Iwasa, Y Okuyama, H Hongo

文献索引：Nakano, Hiroto; Iwasa, Kazuto; Okuyama, Yuko; Hongo, Hiroshi Tetrahedron Asymmetry, 1996 , vol. 7, # 8 p. 2381 - 2386

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被引用次数: 20

摘要

The lipase-catalyzed asymmetric resolution of 2-azabicyclo [2.2. 1] hept-5-en-3-ones is reported; non-racemic chiral 2-azabicyclo [2.2. 1] hept-5-en-3-ones were obtained conveniently by lipase-catalyzed enantioselective transesterification or hydrolysis of N- hydroxymethyl-2-azabicyclo [2.2. 1] hept-5-en-3-one or N-acyloxymethyl-2-azabicyclo [2.2. 1] hept-5-en-3-one.