Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues

…, J Singh, JH Perlman, MC Gershengorn

文献索引：Jain, Rahul; Singh, Jatinder; Perlman, Jeffery H; Gershengorn, Marvin C Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 1 p. 189 - 194

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被引用次数: 25

摘要

We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives.