… (Levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl and 2-(Levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl Groups as Novel Base-Labile Groups for 5′-Hydroxy Protection …

K Kamaike, T Namiki, E Kawashima

文献索引：Kamaike, Kazuo; Namiki, Takashi; Kawashima, Etsuko Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 4 p. 469 - 487

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被引用次数: 2

摘要

Abstract The 6-(levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl (LMM o NBz) and 2- (levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl (LMM p NBz) groups were developed as novel base-labile groups for 5′-hydroxy protection in solid-phase oligonucleotide synthesis. A comparative study of the utility of LMM o NBz, LMM p NBz, and 2- (levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) groups is described.