Synthesis and Anxiolytic Activity of Some Novel 5-oxo-1, 4-oxazepine Derivatives

…, M MA Khalifa, H El-Sehrawi, E Fayed…

文献索引：AbdelFattah, Bothiana A.; Khalifa, Maha M.A.; El-Sehrawi, Hend; Fayed, Eman; Bayoumi, Ashraf; Said, Makarem Letters in Drug Design and Discovery, 2011 , vol. 8, # 4 p. 330 - 338

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摘要

A novel synthetic procedure for a series of 4-Aryl-3-phenyl-6, 7, 8, 9-tetrahydro-benzothieno [3, 2-f][1, 4] oxazepin-5 (4H)-one 8a-s derivatives had been described. Six compounds 8a, b, h, j, m, s were selected and submitted to pharmacological evaluation for anxiolytic activity in the open field test. All the test compounds except 8b significantly reduced the exploratory activity and the emotionality of the rats in the open-field. These inhibitory results are in ...