Tetrahedron: Asymmetry

Studies on the chemoenzymatic synthesis of (R)-and (S)-methyl 3-aryl-3-hydroxypropionates: the influence of toluene-pretreatment of lipase preparations on …

P Borowiecki, M Bretner

文献索引：Borowiecki, Pawel; Bretner, Maria Tetrahedron Asymmetry, 2013 , vol. 24, # 15-16 p. 925 - 936

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被引用次数: 7

摘要

Abstract Two series (para-and meta-substituted) of racemic methyl esters of 3-aryl-3- hydroxypropionic acid were prepared after which the enantiomers were separated by an enzyme-catalyzed transesterification. Several lipases were investigated as the catalyst. The influence of the enzyme pretreatment, as well as substrate concentration, reaction temperature, stirring manner, and substrate conversion on the stereochemical outcome of ...