Synthesis and antiviral evaluation of the 2′-C-methyl branched derivative of a nucleoside analog inhibitor of RNA viral infections, T-1106

…, C Counor, R Storer, G Gosselin

文献索引：Pierra, Claire; Counor, Clement; Storer, Richard; Gosselin, Gilles Collection of Czechoslovak Chemical Communications, 2011 , vol. 76, # 11 p. 1327 - 1333

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被引用次数: 1

摘要

Abstract An example of a 2′-C-methyl branched nucleoside analogue bearing 3, 4-dihydro- 3-oxopyrazine-2-carboxamide as the base, namely 4-(2-C-methyl-β-D-ribofuranosyl)-3-oxo- 3, 4-dihydropyrazine-2-carboxamide, is reported. This compound was synthesized following a Vorbrüggen's glycosylation procedure in a few steps. When evaluated in cell culture experiments against a broad range of viruses, this compound did not exhibit any ...