A novel series of 2, 5-substituted tryptamine derivatives as vascular 5HT1B/1D receptor antagonists

…, S MacLennan, N Mathews, S Dodsworth…

文献索引：Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362

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被引用次数: 46

摘要

The design, synthesis, and activity of a novel series of 2, 5-substituted tryptamine derivatives at vascular 5HT1B-like receptors is described. Several important auxiliary binding sites of the 5HT1B-like receptor have been proposed following various modifications to the 2- substituent and especially to the methylene-or ethylene-linked 5-side chain. Careful design of new molecules based on a proposed pharmacophoric model of the 5HT1B-like receptor ...