New quinolone antibacterial agents. Synthesis and biological activity of 7-(3, 3-or 3, 4-disubstituted-1-pyrrolidinyl) quinoline-3-carboxylic acids

…, JM Domagala, CL Heifetz, JP Sanchez…

文献索引：Hagen; Domagala; Heifetz; Sanchez; Solomon Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 849 - 854

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被引用次数: 32

摘要

Method B in the Experimental Section). 4-Phenyl-3-pyrrolidinamine (15e) 12 and N-(3- methyl-3-pyrrolidinyl)-acetamide (18a) 13 used for compounds 19e and 20a were prepared according to literature procedures. For the synthesis of 4-phenyl-3-pyrrolidinemethanamine (150, the