Tetrahedron letters

Convenient synthesis of furan-3-carboxylic acid and derivatives

N Zanatta, D Faoro, SC Silva, HG Bonacorso…

文献索引：Zanatta, Nilo; Faoro, Debora; Silva, Simone C.; Bonacorso, Helio G.; Martins, Marcos A.P. Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5689 - 5691

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被引用次数: 26

摘要

In this work, a simple and convenient method to prepare furan-3-carboxylic acid and derivatives from the readily available 4-trichloroacetyl-2,3-dihydrofuran 1, is presented. The synthetic potential of 1 for the synthesis of isoxazoles, 12 pyrazoles, 13 pyrimidines, [14], [15] and [16] 3-aminomethylene-dihydro-furan-2-ones, 17 and analogues of cyclophosphamide, 18 has been reported. ... The synthesis of 3-carbonylfuran derivatives was carried out in two steps ( ...