Synthesis and biological evaluation of 3, 4-diaryloxazolones: a new class of orally active cyclooxygenase-2 inhibitors

C Puig, MI Crespo, N Godessart, J Feixas…

文献索引：Journal of Medicinal Chemistry, , vol. 43, # 2 p. 214 - 223

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被引用次数: 78

摘要

... Journal of Medicinal Chemistry. ... Chemistry. The synthetic route for the sulfones 1−8 is outlined in Scheme 1. The commercially available 1-(4-methanesulfonylphenyl)ethanone was converted to the phenacyl alcohol 35 through the bromo derivative 34. ...