Synthesis and biological evaluation of polyhydroxy benzophenone as mushroom tyrosinase inhibitors

J Wu, X Hu, L Ma

文献索引：Wu, Jianlong; Hu, Xuesen; Ma, Lin Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 3 p. 449 - 452

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被引用次数: 2

摘要

A series of polyhydroxy benzophenone were synthesized and evaluated as mushroom tyrosinase inhibitors. The results demonstrated that most of the target compounds had remarkable inhibitory activities on mushroom tyrosinase. Among all these compounds, 2, 3, 4, 3′, 4′, 5′-hexahydroxy-diphenylketone 10 was found to be the most potent tyrosinase inhibitor with IC50 value of 1.4 μM. In addition, the inhibition kinetics analyzed by ...