Design, synthesis and evaluation of carbazole derivatives as PPARα/γ dual agonists and antioxidants

…, U Ramachandran, K Srinivasan, P Ramarao…

文献索引：Kumar, Rakesh; Ramachandran, Uma; Srinivasan, Krishnamoorthy; Ramarao, Poduri; Raichur, Suryaprakash; Chakrabarti, Ranjan Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 13 p. 4279 - 4290

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被引用次数: 26

摘要

A series of hydroxycarbazole derivatives were synthesized and evaluated for PPARα/γ dual agonist as well as antioxidant activities. While most compounds showed good antioxidant activity, some compounds were identified as potential PPARα/γ dual agonists as well. Compounds 10a and 16 were found to be active in animal studies.