Bioorganic & medicinal chemistry letters

Efficient synthesis of 8-oxo-dGTP: a mutagenic nucleotide

S Nampalli, S Kumar

文献索引：Nampalli, Satyam; Kumar, Shiv Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1677 - 1679

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被引用次数: 15

摘要

An efficient synthesis of mutagenic and oxidative DNA damage product, 8-oxo-dGTP (4) has been achieved in high yield, along with a serendipitous generation of 8-dimsyl-dG (2). In combination with dPTP (5), 8-oxo-dGTP (4) can be formulated into a kit for investigating DNA random mutagenesis.