(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H 3 receptors

…, X Ligneau, S Elz, S Reidemeister, CR Ganellin…

文献索引：Sasse; Stark; Ligneau; Elz; Reidemeister; Ganellin; Schwartz; Schunack Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 5 p. 1139 - 1149

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被引用次数: 29

摘要

In the search for new ligands of the histamine H3 receptor, novel diarylalkyl carbamates (1– 19) were synthesized as derivatives of 3-(1H-imidazol-4-yl) propanol and-ethanol. Carbamates were built up via isocyanates either from corresponding amines by reaction with diphosgene or from related carboxylic acid/diphenylphosphoryl azide and the alcoholic component. Sterically hindered amines were prepared in a two-step reaction sequence ...