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3-Phenyl-5-quinolinemethanol antimalarials

A Makriyannis, JW Wilson…

文献索引:Makriyannis,A. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 118 - 122

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被引用次数: 7

摘要

Special Skraup procedures have been developed for the synthesis of a series of new 3- phenyl-5-quinolinecarboxylic esters. These esters have been employed as starting materials for the elaboration of a series of cu-dialkylaminomethyl-3-phenyl-5-quinolinemethanols via the corresponding acid chlorides, diazo ketones, bromo ketones, and epoxides. Alternate routes to the desired 3-phenyl-5-quinolinemethanols were also investigated. In the case of ...