Discovery of 7-arylsulfonyl-1, 2, 3, 4, 4a, 9a-hexahydro-benzo [4, 5] furo [2, 3-c] pyridines: Identification of a potent and selective 5-HT 6 receptor antagonist showing …

R Tripathy, RJ McHugh, ER Bacon, JM Salvino…

文献索引：Tripathy, Rabindranath; McHugh, Robert J.; Bacon, Edward R.; Salvino, Joseph M.; Morton, George C.; Aimone, Lisa D.; Huang, Zeck; Mathiasen, Joanne R.; Dicamillo, Amy; Huffman, Mark J.; McKenna, Beth A.; Kopec, Karla; Lu, Lily D.; Qian, Jie; Angeles, Thelma S.; Connors, Thomas; Spais, Chrysanthe; Holskin, Beverly; Duzic, Emir; Schaffhauser, Herve; Rosse, Gerard C. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1421 - 1426

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被引用次数: 9

摘要

Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine6 (5-HT6) receptor antagonists show beneficial effect on cognition in several animal models. Based on a pharmacophore model reported in the literature, we have designed and successfully identified a 7- benzenesulfonyl-1, 2, 3, 4-tetrahydro-benzo [4, 5] furo [2, 3-c] pyridine (3a) scaffold as a ...