The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore

DG Washburn, DA Holt, J Dodson, JJ McAtee…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 17 p. 4979 - 4984

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被引用次数: 14

摘要

... Bioorganic & Medicinal Chemistry Letters. ... 4 and 6 Due to the association of both TRPC3 and TRPC6 with cardiac hypertrophy, and the unmet medical need associated with cardiovascular disease, a small molecule drug discovery program was undertaken which focused on ...