Abstract Purpose. This study aims to evaluate a cytochrome P450-based tamoxifen- isoflavone interaction and to determine the mechanisms responsible for inhibitory effects of isoflavones (eg, genistein) on the formation of α-hydroxytamoxifen. Methods. Metabolism studies were performed in vitro using female rat liver microsomes. The effects of genistein and an isoflavone mixture on tamoxifen metabolism and the inhibition mechanism were ...
