Fluorinated N-[2-(haloalkyl) phenyl] imidoyl chloride, a key intermediate for the synthesis of 2-fluoroalkyl substituted indole derivatives via Grignard cyclization process
Fluorinated N-[2-(haloalkyl) phenyl] imidoyl chloride, which was readily available from the corresponding anilines by using Uneyama's one-pot synthesis of fluorinated imidoyl chloride, was found to be a key intermediate for the facile synthesis of 2-fluoroalkyl substituted indole derivatives via the Grignard cyclization process. The bromination of 3- methyl group of 3-methyl-2-trifluoromethyl indole with NBS/CCl4 led to the formation of 3- ...
