Tetrahedron

A formal total synthesis of the marine alkaloid aaptamine

EL Larghi, BV Obrist, TS Kaufman

文献索引：Larghi, Enrique L.; Obrist, Blaise V.; Kaufman, Teodoro S. Tetrahedron, 2008 , vol. 64, # 22 p. 5236 - 5245

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被引用次数: 33

摘要

A new strategy for the synthesis of benzo [de][1, 6] naphthyridine derivative 2, 3, 3a, 4, 5, 6- hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2, 3, 3a, 4, 5, 6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural ...