Tetrahedron

Simple and efficient synthesis of 2, 6-dialkyl-3, 5-dialkoxycarbonyl-4-(3-aryl-1-phenyl-pyrazol-4-yl) pyridines using TPAP/NMO as a catalyst under mild conditions

…, K Ramamoorthy, S Sundarrajan, S Ramakrishna

文献索引：Murugan; Ramamoorthy; Sundarrajan; Ramakrishna Tetrahedron, 2011 , vol. 67, # 16 p. 2998 - 3002

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被引用次数: 5

摘要

Oxidation of 1,4-DHP has received considerable attention because DHP based calcium channel blockers are oxidatively converted to pyridine derivatives by the action of cytochrome P450 in the liver. 15b, 15 and 15a Efforts on the synthesis of heteroaryl DHP chemistry mimicking NADH coenzyme is recently expanding to explore the mechanisms and utilizing them for a variety of synthetic reactions. Therefore, the synthesis of these moieties has become of interest to ...