Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies

…, P Yogeeswari, E De Clercq, C Pannecouque…

文献索引：Judge, Vikramjeet; Narasimhan, Balasubramanian; Ahuja, Munish; Sriram, Dharmarajan; Yogeeswari, Perumal; De Clercq, Erik; Pannecouque, Christophe; Balzarini, Jan Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1451 - 1470

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被引用次数: 37

摘要

Abstract A series of isonicotinic acid hydrazide derivatives (1–19) was synthesized and tested in vitro for antimycobacterial activity against Mycobacterium tuberculosis and antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger and the results indicated that the compounds with OH, SCH 3, and OCH 3 groups were found to be active against the tested strains. None of ...