Bioorganic & medicinal chemistry

Synthesis, screening and quantitative structure–activity relationship (QSAR) studies of some glutamine analogues for possible anticancer activity

K Srikanth, CA Kumar, B Ghosh, T Jha

文献索引：Srikanth; Kumar; Ghosh, Balaram; Jha, Tarun Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2119 - 2131

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被引用次数: 46

摘要

We described the syntheses, biological activities and QSAR studies of 36 new 5-n- substituted-2-(substituted benzenesulphonyl) glutamines 6–41 with different substitutions. These compounds were designed as structural analogues of most reactive amino acid,'glutamine'(GLN), especially in the tumor cells. They present the new basic lateral chains at R5 position as well as different substitutions at 2′, 3′, 4′, and 5′ positions ...